Synovial Fluid in Gout

Gout without crystals on initial synovial fluid analysis.

In five patients with acute arthritis in whom gout was eventually documented, an initial synovial fluid analysis failed to reveal urate crystals. Four of the patients were seen in one hospital during a period of 30 months in which 103 cases of gout were documented on initial aspiration. While this is an uncommon event, the importance of being able to make a definitive diagnosis of gout is such ...

Synovial fluid in antiquity.

7 Hall N D, Gillan A H. Effects of antirheumatic drugs on protein sulphydryl reactivity of human serum. J Pharm Pharmacol 1979; 31: 676-80. 8 Jellum E, Munthe E, Guldal G, Aaseth J. Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice. Ann Rheum Dis 1980; 39: 155-8. 9 Munthe E, Guldal G, Jellum E. Increased intracellular glutathione during penici...

Wide-field imaging of birefringent synovial fluid crystals using lens-free polarized microscopy for gout diagnosis

Gout is a form of crystal arthropathy where monosodium urate (MSU) crystals deposit and elicit inflammation in a joint. Diagnosis of gout relies on identification of MSU crystals under a compensated polarized light microscope (CPLM) in synovial fluid aspirated from the patient's joint. The detection of MSU crystals by optical microscopy is enhanced by their birefringent properties. However, CPL...

Synovial perfusion and synovial fluid solutes.

answer goes back to the cardinal signs of inflammation. The redness and heat of this state relate directly to increased local blood supply, and these critical findings cannot be examined systematically without accurate quantification of flow. Further, the imbalances of vascular permeability and tissue clearance that lead to tissue swelling cannot be evaluated usefully without an understanding o...

Hemolytic Complement in Synovial Fluid.